![]() ![]() Per person sequencing costs for cancer are high when tumour/blood pairs require testing. Total costs were most sensitive to consumables and sequencing activities driven by commercial prices. Capital costs for the sequencers were an additional AU$34–197 (2018 US$24–67) per person. ![]() Cost proportions were highest for library preparation/sequencing materials (average 76.8% of total costs), sample extraction (8.1%), data analysis (9.2%) and data storage (2.6%). Costs were also aggregated according to labour, consumables, testing, equipment and ‘other’ categories. Estimated costs to the public health system for resources were categorised into seven distinct activities in the sequencing process: sampling, extraction, library preparation, sequencing, analysis, data storage and clinical reporting. Deterministic sensitivity analyses addressed the uncertainty in the estimates. Aggregated resource data were captured for a total of 1433 patients and point estimates of per patient costs were generated. Sequencing was undertaken for patients with lung, breast, oesophageal cancers, melanoma or mesothelioma. We performed a cost-analysis using gross and micro-costing approaches for genomic sequencing performed during 2017/2018 across different settings in Brisbane, Australia. ![]() The objective of the study was to examine and categorise the complete costs involved in genomic sequencing for a range of applications within cancer settings. Despite the rapid uptake of genomic technologies within cancer care, few studies provide detailed information on the costs of sequencing across different applications. ![]()
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